Smart bombing Melanoma
“It is not the strongest of the species that survives, nor the most intelligent, but the one most responsive to change.”
~Charles Darwin~
“Most tumors arise from a single normal cell through a sequential evolutionary process of mutation and selection. Tumors are initiated by escaping non-immune surveillance, which includes defective DNA repair, gene alternation, resistance to apoptosis and loss of intercellular contact inhibition. Tumor cells harbor mutations in a number of critical genes that provide selective advantages at various stages during the evolution of the tumor. The tumor cells that circumvent the tumor suppressor mechanisms of the non-immune surveillance process are edited by the immune system, resulting in the selection of a resistant tumor variant. The selection of the tumor cell is further shaped by its interactions with cells and other factors in its microenvironment. Tumor evolution is thought to adhere to Darwinian principles by escaping both non-immune (intrinsic) and immune (extrinsic) responses against self-altered tumor cells. At end-stage, tumors have escaped both non-immune and immune surveillance with increased threshold of apoptosis. Combination therapy has been proposed, by exploring the non-immune and immune suppressive nature of the tumor, and has been found to have a therapeutic efficiency on tumor regression as compared with monotherapies. The combination of immunotherapy and other different modalities, especially vaccines, with conventional anticancer therapies with optimized dosage and scheduling can offer synergistic antitumor effects.”
Source: http://www.cellbiolint.org
Chemotherapy
The combination of chemotherapy and immunotherapy is synergized as chemoimmunotherapy; chemotherapy can kill or slow the growth of cancer cells and immunotherapy stimulates or restores the ability of the immune system to fight against cancer (Emens and Jaffee, 2005; Gulley et al., 2007). Apoptotic death, particularly massive apoptosis by chemotherapy, can be a priming event for antitumor immunity, allowing the tumors to act as its own vaccine by releasing a large amount of tumor antigen. This priming event sets the stage and the direction of the immune response. With the right tumor antigen, the activated T-cells (CTL’s) Cytotoxic T Lymphocytes can zero in on their target, the tumor cell. Smart bombing Melanoma!!!!!
Source: http://thefutureofthings.com/articles/1012/smart-bombing-cancer.html
Source: NCI
“It is not the strongest of the species that survives, nor the most intelligent, but the one most responsive to change.”
~Charles Darwin~
Take Care,
Jimmy B
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