Holiday Wishes to you All !! Melanoma..Jim Breitfeller

I would like to wish each and every one of my carepage friends the warmest and deepest greetings this Holiday Season. We been through a lot and with the comfort of family and friends we can beat the Beast Melanoma.

It has been truely a renewed emergence in Melanoma therapy this past year with TWO therapies being FDA approved that extends survival for us Melanoma patients. At this time of the Season, please relect on the Worriors that are no longer with us, but made this all possible by offering their life to the progress of science.

They truely have shown us the gift of giving.

They truely are my/our HEROS!!!

We will miss them dearly.

Happy Holidays




“It is not the strongest of the species that survives, nor the most intelligent, but the one most responsive to change.”

~Charles Darwin~

Take Care,

Jimmy B

FDA approval of Roche melanoma drug (Vemurafenib) may come early

Reuters) - Regulators are moving quickly with Roche's application for targeted melanoma drug vemurafenib, which could receive approval as early as this week, according to a source familiar with the situation.

Vemurafenib, whose brand name is Zelboraf

Source: FDA approval of Roche melanoma drug may come early



Your tumors must be BRAFV600E positive




“It is not the strongest of the species that survives, nor the most intelligent, but the one most responsive to change.”

~Charles Darwin~

Take Care,

Jimmy B

ASCO Review with Dr. John Kirkwood on Melanoma Therapies..jim Breitfeller

The full Audio of the Dr. Kirkwood interview at ASCO 2011


Please if you get a chance, listen to the full interview of Dr. John Kirkwood on the lastest therapies for Melanoma. It might help save your life or loveone's life.

Get a cup of coffee and a pad and pencil.

Enjoy




“It is not the strongest of the species that survives, nor the most intelligent, but the one most responsive to change.”
~Charles Darwin~

Take Care,
Jimmy B

Bristol, Roche team up on melanoma study..Jim Breitfeller

By Bill Berkrot and Lewis Krauskopf

NEW YORK | Thu Jun 2, 2011 1:30pm EDT

NEW YORK (Reuters) - Bristol-Myers Squibb and Roche Holding AG said on Thursday they would evaluate their respective cancer drugs as a potential combination therapy for metastatic melanoma.

The collaboration involves a Phase I/II study with Bristol's recently approved Yervoy and Roche's experimental drug, vemurafenib, to determine the safety and efficacy of the combination in treating the deadliest form of skin cancer.

The announcement comes as the American Society of Clinical Oncology meeting begins this weekend in Chicago, where emerging treatments for melanoma will be in the spotlight.

Among the most eagerly anticipated studies being presented at the ASCO meeting will be a Phase III trial intended to show that vemurafenib extended the lives of patients with advanced melanoma, and another study comparing Yervoy to chemotherapy in patients with the fatal disease.

Yervoy won U.S. approval in March for patients with inoperable or metastatic melanoma, making it the first new treatment option in many years for patients for whom there was little hope and virtually no effective medicines.

Roche and Japanese drugmaker Daiichi Sankyo Co recently submitted U.S. and European applications seeking approval for vemurafenib. The drug was developed by Roche's Genentech unit and Plexxikon, which was recently acquired by Daiichi.

Vemurafenib, a so-called BRAF inhibitor, is designed to selectively target and inhibit a mutated form of the BRAF protein found in about half of all cases of melanoma. The combination study with Yervoy will be in patients with BRAF-mutated metastatic melanoma, Roche said.

Roche is also developing a combination diagnostic to help identify those patients with the BRAF mutation who are likely to benefit from vemurafenib.

"We are entering a new era for melanoma, and are committed to studying exciting combinations with investigational medicines in our own pipeline," Roche Chief Medical Officer Hal Barron said in a statement.

If proven effective and approved the Yervoy-vemurafenib combination would be an extremely expensive treatment option that could meet with reimbursement resistance from government programs and health insurers.

Bristol priced a four-infusion course of Yervoy at about $120,000. Vemurafenib will likely also command premium pricing if it too demonstrates an ability to help patients live longer.

More than 70,000 people in the United States and 160,000 worldwide are diagnosed with melanoma each year, according to the American Cancer Society. The five-year survival rate for the aggressive cancer is just 15 percent.

Source:http://www.reuters.com/article/2011/06/02/us-bristol-roche-melanoma-idUSTRE75151W20110602


All I can say.... It is about Time!!!! Lets all work together for the common good.


“It is not the strongest of the species that survives, nor the most intelligent, but the one most responsive to change.”
~Charles Darwin~

Take Care,

Jimmy B

A call for patients that failed PLX-4032 Melanoma Jim Breitfeller

Genentech has just opened a study for people who have taken the Plexxikon/Roche/Genentech BRAF inhibitor, also known as PLX 4032. This study is a combination trial using PLX plus a MEK inhibitor. Some folks from this board have been in the BRAF/MEK trial being run by GSK, and this new trial is similar. One criteria, though, is that you must have taken the Plexxikon drug and have developed resistance to that drug. Currently three sites are open: Dr. Gajewski in Chicago, Dr. Ribas in UCLA, and Dr. Gonzalez in Denver. Four more sites will open soon. You can go to this link to find out information about melanoma relevant clinical trials, including this one: http://www.emergingmed.com/networks/MRF



Source: Tim--MRF



“It is not the strongest of the species that survives, nor the most intelligent, but the one most responsive to change.”



~Charles Darwin~

Take Care,

Jimmy B

Expanded access With RO5185426 in Patients With Metastatic Melanoma..Jim Breitfeller

Expanded access With RO5185426 in Patients With Metastatic Melanoma.
The locations are limited.

The drug is called RO5185426, which is interchangeable with PLX4032 and RG7204. Also, you must be Braf positive and failed a prior therapy.

Expanded access With RO5185426 in Patients With Metastatic Melanoma




“It is not the strongest of the species that survives, nor the most intelligent, but the one most responsive to change.”

~Charles Darwin~
Take Care,
Jimmy B

Promising new Melanoma Drug, PLX4032: Questions and Answers

Promising new melanoma drug: Questions and answers


By Liz Szabo, USA TODAY

A new drug for the treatment of advanced melanoma is generating rare excitement and optimism among cancer doctors. USA TODAYasked experts to explain the drug's benefits and limitations.
Q: Why is the drug promising?

A: The drug, PLX4032, shrank tumors in 26 of 32 melanoma patients who had a key mutation in their tumors, according to a study in today's New England Journal of Medicine.

That's "remarkable," because patients in small, early trials such as this often get no benefit at all. Typically, experimental drugs shrink tumors in only 5% to 10% of patients, says Keiran Smalley of the Moffitt Cancer Center and Research Institute in Tampa, who wasn't involved in the study.

Some patients began showing improvement within only a few days, says Lynn Schuchter of the University of Pennsylvania, who also worked on the study.

Q: Were those patients cured?

A: In two patients, tumors disappeared, and some patients' disease remains in check. It's too early to know whether patients will stay in remission, however. The median remission was more than seven months, the study says.

But even shrinking tumors is relatively rare in advanced melanoma that has spread to other organs. The two approved drugs for melanoma — a chemotherapy called dacarbazine and an immune therapy called interleukin-2 — shrink tumors for only about 10% to 20% of patients, the study says.

Q: Does the drug help all patients?

A: No, it helps only the roughly 50% of patients whose tumors have the mutations in a gene called BRAF, the study says. Patients who don't have the mutation get no benefit.

If the drug is approved, doctors probably will begin testing all patients with advanced melanoma for the mutations. A test such as this probably would cost a few hundred dollars, says the study's lead author, Keith Flaherty of Massachusetts General Hospital in Boston.

Q: How is the drug different from other treatments?

A: Unlike conventional chemo, which kills all fast-growing cells, the new drug — also known as RG7204 — is considered a "targeted therapy" because it aims to block a specific mutation found only in certain melanoma cells.

Q: What about side effects?

A: Because PLX4032 leaves most healthy cells alone, it causes far fewer side effects than chemo, Flaherty says. High-dose IL-2, for example, can cause life-threatening side effects and is given only in the hospital, so patients can be closely monitored. Patients can take PLX4032, a pill, at home.

But even relatively mild side effects can become bothersome over time, says Vernon Sondak of the Moffitt Cancer Center and Research Institute in Tampa, who wasn't involved in the study.

If PLX4032 helps keep patients alive a long time — either by itself or when combined with other experimental drugs — patients may be more troubled by fatigue, rash and joint pain, Sondak says.

Q: Who financed the study?

A: The study was paid for by the drug's co-developers, Plexxikon and Roche Pharmaceuticals.

Q: What will it cost?

A: The companies haven't announced a price, because the drug is still in early trials. Flaherty notes, however, that many new cancer therapies cost $5,000 to $7,000 a month.

Q: Is it possible to get the new drug?

A: Yes. Doctors are still enrolling patients with advanced melanoma in a large trial of 680 patients who haven't gotten other treatment. Additional studies are expected to be launched next year, Flaherty says. More information about PLX4032 is available by calling 888-662-6728.

Other experimental drugs for melanoma — including ones very similar to PLX4032 — also are being developed. More information can be found at clinicaltrials.gov

Q: When might the drug be approved?

A: If additional studies are positive, Roche Pharmaceuticals plans to apply for FDA approval in 2011, spokeswoman Amy Berry says. In June, PLX4032 was given "fast-track" status by the Food and Drug Administration — a process that helps speed up development of drugs that fill unmet needs.

Source:http://www.usatoday.com/news/health/2010-08-26-melanomaQA_ST_N.htm


Since it helps only the roughly 50% of patients whose tumors have the mutations in a gene called BRAF, Ipilimumab,PD-1 and Interluekin-2 would be other therapies to try.

My gut feeling is that we can beat Melanoma with combinatorial Therapy.

We just need to get the Drug companies and the Oncologists on board




“It is not the strongest of the species that survives, nor the most intelligent, but the one most responsive to change.”

~Charles Darwin~

Take Care,

Jimmy B

The Cancer Trial Bristol and Roche Must Do Now..Melanoma ..Jim Breitfeller

The Cancer Trial Bristol and Roche Must Do Now

Author: Robert Langreth
Treatments
Aug. 26 2010 - 12:31 pm

Novartis’ Gleevec is an exception. Curing cancer won’t happen with a single drug. Common cancers are too complicated and have too many mutations. The solution, many cancer researchers hope, are smart drug combos that hit multiple tumor weak points at once.

But what happens when two drug companies own the experimental drugs that need to be combined?

The small world of melanoma all of sudden faces this lucky problem. For decades melanoma was a barren wasteland of drug development. Almost nothing worked.


Image via Wikipedia
Now there are two promising new drugs. Ipilimumab from Bristol-Myers Squibb stimulates the immune system against cancer. Based on pioneering research by James Allison, the drug boosted patient survival by three months, a big trial found.

Meanwhile, PLX4032 from Roche and Plexxikon works via a different mechanism and shrinks tumors in a mind-boggling 80% of melanoma patients whose tumors have a mutation called in a gene called BRAF, These results were published this week in the New England Journal of Medicine. But the effects often don’t last long; resistance hits after a matter of months. It has not been proven to extend how long patients live. GlaxoSmithkline is testing a similar drug.

The obvious thing to do: combine the Roche and Bristol drugs in a trial to see if both drugs produce a powerful one-two punch. The logic, points out Memorial Sloan Kettering melanoma expert Paul Chapman, is compelling. Both drugs work by different mechanisms and don’t have obvious overlapping side effects. The Roche braf drug kicks in quickly, which can help symptoms, while the Bristol-Myers drug takes months to act, only occasionally produces big tumor shinkage. But when it does the effects can be almost miraculous.

Dead tissue produced by the anti-tumor effects of the Roche drug, could help stimulate the immune system and enhance the impact of the Bristol drug. In test tube experiments, blocking BRAF protein in melanoma cells appeared to enhance the ability of the immune system’s killer t-cells to recognize melanoma, according to a recent Massachusetts General Hospital study.

The good news, says Massachusetts General Hospital’s Keith Flaherty, is that both Bristol and Roche appear willing to collaborate. Flaherty says that cancer doctors cajoled the two sides to discuss a combo trial at the June ASCO meeting of cancer doctors. “This discussion went better than any of us expected,” he says. Both Roche and Bristol confirmed to Forbes that they are exploring combination therapy.

“Everyone wants to do it. It is a no-brainer,” says Chapman. But the logistics are extremely tricky, he says, and a trial design has not been finalized. Whose drug is the “control therapy” to which the combo is compared? Which company gets the patent on the combo, if there is one? Who gets the blame if the combo produces nasty side effects? “There are a lot of wild cards here, we are working on this, it is going to happen,” says Chapman. Another issue: both companies are naturally focused on getting their drugs approved individually first.

It is heartening that Bristol and Roche are amenable to getting together. Too often, corporate bureaucracy has trumped patient needs. One exception is a dual cancer drug trial that Merck and AstraZeneca announced last year.

Flaherty says that a combination trial won’t begin until April of 2011 at earliest. That is far too long. For melanoma patients’ sake, Bristol and Roche need to begin this trial sooner rather than later.

Source:http://blogs.forbes.com/robertlangreth/2010/08/26/the-cancer-trial-bristol-and-roche-must-do-now/?boxes=businesschannelsections




This combinatorial is another therapy that has a real potential. It combines IFN,DTIC,Anti-CTLA-4 (Ipilimumab) and IL-2. it has worked for a number od Melanoma patientss.

We need to get these drug companies to work together for the common good. There is enough room for all the drug companies to get a piece of the Melanoma Action. One therapy will not work.

Combinatorial therapy is the road to success.

"FOLLOW THE YELLOW BRICK ROAD"

“It is not the strongest of the species that survives, nor the most intelligent, but the one most responsive to change.”

~Charles Darwin~

Take Care,
Jimmy B

Faltering Cancer Trials Melanoma.. Jim Breitfeller

Faltering Cancer Trials
Editorial
Published: April 24, 2010


The government’s system for judging the clinical effectiveness of cancer treatments, recently found to be in “a state of crisis,” must be repaired.

Here is a recent article from the New York Times. Thanks to Ed a carepage friend and colleage for bringing this to my attention.


Source:http://www.nytimes.com/2010/04/25/opinion/25sun1.html

Faltering Cancer Trials



We need the Patients to unite and get the best therapy for their condition. This is not rocket science, it is biochemistry at it's best. We need Big Pharma(Bristol Myer Sqiubb, Novartis,Pfizer, Plexikkon, Hoffman La Roche and others) to step up to the plate and do what is ethical. Not just looking at their bottom line. Without patients/consumers, these drug companies would not exist.

Our future survival is in our hands. The cure is out there. We need the medical community to take notice.




Take Care,
Jimmy B

Future Directions in Targeted Therapy for Melanoma..Jim Breitfeller

Future Directions in Targeted Therapy for Melanoma

“Our improved understanding of the molecular pathways that underlie the progression of melanoma has revealed numerous potential therapeutic approaches. We now face the challenge of developing targeted therapies directed at signaling pathways that are activated through mutations. Single-agent therapy is unlikely to be markedly successful,so there is also a pressing need to evaluate combination therapies, both with multiple targeted therapies and with targeted therapies plus conventional chemotherapeutic agents. It is hoped that these approaches will result in effective treatment options for patients with metastatic melanoma.”

~Dr. Keith T. Flaherty~


The Complexity of the T cell

In the midst of many promising discoveries, it became apparent to Dr. Allison and other researchers working in the field that stimulation of T cell response was more complicated than originally thought. As Dr. Allison and others discovered, first the T cell uses a structure called the antigen receptor to recognize a foreign antigen in the system (created by infecting viruses or bacteria, or new antigens found in tumor cells). Using an automobile as an analogy, Dr. Allison likens this step to turning the key in the car's ignition. "The car is running, but it's not going anywhere."

Recognition is not enough. Dr. Allison explains: "A second signal is also required, which, in the car analogy, would be the foot on the gas pedal." This second signal occurs when a particular family of molecules called the B7 molecule engages a molecule known as CD28 found on the surface of the T cell. Only these molecules are capable of initiating T cell response.

The final part of the car analogy is the immune system's brake -- an immune-regulating molecule, whose function was discovered by Dr. Allison's lab, known as cytotoxic T lymphocyte-associated antigen-4 (CTLA-4). CTLA-4 inhibits activated T cells in the immune system, preventing them from attacking the body's own tissues

It is now well accepted that recognition of specific antigen by the TCR is not sufficient for activation but that a second antigen nonspecific "co-stimulatory" signal is required. We have demonstrated that this second signal is provided the co-stimulatory receptor CD28 upon recognition of its counter-receptors, members of the B7 family, on the antigen-presenting cell. CD28 engagement is required under most situations for IL-2 production and proliferation. The lack of a CD28-mediated co-stimulatory signal upon TCR engagement can result in the induction of a long-lived state of nonresponsiveness.

We have recently found that co-stimulation is more complex than previously thought. CTLA-4, a homolog of CD28, also binds members of the B7 family, and binds them with affinities much higher than CD28. A wealth of data accumulated in the past few years show that CTLA-4 is an important downregulator of T cell responses. We have proposed that CTLA-4 plays a critical role in both the initiation and termination of T cell responses. According to this view, T cell activation is a dynamic process that is determined by the strength of the TCR signal; the strength of co-stimulation provided by CD28; and the magnitude of inhibitory signals generated by CTLA-4.

We have also demonstrated that CTLA-4 blockade can be used in combination with other methods of immunopotentiation or even conventional chemotherapy to obtain rejection of resistant tumors. We are currently examining the cellular and molecular mechanisms of the anti-tumor effect. The strategies we have developed in the mouse are currently in clinical trials for evaluation of effectiveness in treatment of prostate cancer and melanoma

Source: Sloan-Kettering Institute

"I believe that we are on the verge of bringing the manipulation of immune responses into the mainstream of cancer therapy," Dr. Allison said. "Recent work in cancer biology has shown that the genetic instability that is inherent in cancer results in a large number of mutations in proteins that create new antigens that the body has never seen before and ought to be readily recognized as foreign by the immune system. If we can kill some tumor cells, either as a result of a vaccine or treatment with more-conventional therapies, using agents such as anti-CTLA-4 ought to result in induction of potent immunity to these new targets. Thus, I believe that it is not unreasonable to think of many of the new targeted therapies as immunosupportive, and to use them in conjunction with the new approaches to enhancing immune responses."

~Dr. James Allison~

We are on the Verge of Harnessing the Immune System to recognize Melanoma cells as foreign. How this plays out will depend on if the Pharmaceutical companies like Bristol-Myer Squibb, Novartis, Pfizer, Hoffman La Roche, Plexikkon and other come together as one, to fight this Monster of a disease. Time will only tell. We owe it to the Patients.






Take care

Jimmy B

Melanoma_Missionary


"Today might be the worst day of your life...but tomorrow could be the best. You just have to get there."
~Unknown~

http://www.box.net/shared/kjgr6dkztj

Melanoma and The Magic Bullet (Monoclonal Antibodies)

There is No Magic Bullet to Cure Melanoma, And We Must Develop Multimodality Strategies..Melanoma..Jim Breitfeller

Expert opinion
“The research efforts directed towards the development of novel therapies for patients with metastatic melanoma have been intense despite disappointing clinical outcomes. It is clear that monotherapy for metastatic melanoma will not be successful, with every study to date yielding minimal clinical outcomes
data. Therefore, we must realize that there is no magic bullet to cure melanoma, and we must develop multimodality strategies to enhance the immune response to melanoma from different angles. This will require an unprecedented collaborative effort by many in order to overcome the historical competition between large pharmaceutical companies striving for ‘total cure’ with their drug.”

~ Dr.Adam I Riker~

We should realize that the future of drug development and design will depend heavily on the recent trend towards molecular medicine, and in particular, gene profiling efforts using gene microarray analysis. We are entering an entire new field of research dedicated to the molecular basis of cancer. Such research has the greatest potential to impact the way we treat patients with melanoma, focusing results on the prognostic significance of particular genes from a melanoma patient and basing clinical decisions as to whether such patients will (or will not) respond to a particular agent. The development of molecular signatures using gene microarray analysis has come to the forefront of existing research efforts identifying patients who may have an aggressive (versus indolent) form of melanoma and those patients with particular prognostic gene
signatures that may predict the response to forms of immunotherapy. The identification of such gene signatures has had important implications in the development of targeted immunotherapies for patients with metastatic disease. Thus, we must focus our efforts towards an improved understanding of the molecular and immunologic events involved in melanoma development and progression. We should also re-evaluate our present approach to immunotherapy and trial design, with many past trials failing to show clinical efficacy because of a lack of appropriate preclinical data that provide the essential rationale to perform such studies.

Source: http://www.southalabama.edu/mci/spf90/riker2.pdf

Immunotherapy of melanoma: a critical review of current concepts and future strategies








Take Care,

Jimmy B

Combinatorial Therapy, Will the Big Pharmaceutical Companies do what Is Ethically Right?Melanoma..Jim Breitfeller

Combinatorial Therapy, Will the Big Pharmaceutical Companies do what Is Ethically Right?




They include Plexikkon,Bristol-Myer Squibb, Pfizer, La Roche and Novartis.


I and other researchers have come to the conclusion that Combinatorial Therapy may be the only way to beat The BEAST, Melanoma



“A very obvious combination that we are trying to move forward now is PLX4032 with ipilimumab. There is unanimity among the academic researchers that this must be investigated. Both companies see the logic, but are reluctant with neither of their drugs yet being FDA approved. As you know ipilimumab (and tremelimumab) have not overwhelmed the FDA yet as they were told to show a response rate greater than 10% and neither drug could do so. Most melanoma researchers believe that there are additional patients who get real and long-term benefit without having their tumors shrink significantly in size, but the randomized trials are needed to show that. The worrying sign is the outcome of the tremelimumab randomized trial. So, now we are down to waiting for the results of the dacarbazine vs. dacarbazine plus ipilimumab phase III trial. If this is negative, we are in trouble as ipilimumab will have no clear path forward with the FDA. If it’s positive, then the idea of moving ahead with combinations becomes much, much easier. But, even it that trial is negative, we know that CTLA-4 blockade can induce phenomenal responses in some. So, in that case, we have to figure out (1) who those patients are and, (2) how to make those responses happen in more patients. The other way of thinking of #2 is that PLX4032 doesn’t work for as long as we would like and that making those responses more durable would be desirable.”


~ Dr. Keith Flaherty ~


“ Mike Weber was kind to forward your paper and email. It appears that you have a very good sense of, and interest in, the immune response to melanoma and to cancer in general. I believe you are right that timing of the various components of the immune response, especially with combination therapies, is important, just as it is in the orchestration of a beautiful symphony.”


~ Dr. Craig Slingluff ~



Dr Markovic,. I thought you might be interested in this combinatorial therapy

“We actually just submitted a paper to this affect in a small clinical trial where we used a conventional chemotherapeutic agent to induce a systemic anti-tumor immune response by simply timing drug delivery. And, it worked! It was a small study, so the data is only descriptive. I'm gearing up to move to a large trial right now.”


~Dr. Svetomir Markovic~



“To answer your last question first: Mutations in B-Raf and N-Ras have been shown to cluster at specific nucleotides. This strongly suggests that there is a cellular mechanism which targets these sites in each gene. However, you are probably right, that anti-CTLA4 and IL2 are working by enhancing immune surveillance of your melanoma.”


~Dr. Natalie Ahn~



“In conclusion, the combination of MART-1/DC with concomitant tremelimumab is feasible in patients with metastatic melanoma, especially when tremelimumab is administered every 3 months, and results in durable objective clinical responses at the higher range of the expected objective tumor response rates with either therapy alone. Therefore, this combination warrants further study in patients with advanced malignant melanoma.”

~Dr. Antoni Ribas~


The rationale for the CTLA-4 and IL-2 combination is once you activated the CD4+ Tcell and it crossprime the CD8+ Tcell , the IL-2 needed for the maintenance and functionality of the CD8+ T-cell.
If lymphocytes are cultured in the presence of Interleukin 2, it results in the development of effector cells which are cytotoxic to tumor cells.

“Fine theory but just theory that has never been tested in relevant clinical setting…”

~Dr. John M. Kirkwood~

"Glad to see your post on this series. From our perspective, the melanoma community isn’t waiting for a “miracle” to fall out of the sky to help patients. It’s clear that no single drug will likely effectively treat the disease; instead, a combination of drugs may be the answer. The Melanoma Research Foundation (MRF) is coordinating the Melanoma Breakthrough Consortium to accelerate research by bringing together leaders in drug development, laboratory and clinical research to find effective treatments. This collaboration will take years off the process. Patients with advanced melanoma have few or no treatment options and there’s no doubt in the urgency of moving forward to test new therapies today. More information is available at http://www.melanoma.org."

~Tim Turnham~
Executive Director
Melanoma Research Foundation




This is why we the patients need the Pharmaceutical companies to work together. Each therapy will not work alone as a single agent. The response rate is between 10 and 22 percent for each therapy. If you do a sequential treatment with the proper dosage and timing, you will see a synergistic outcome.

“There are three parts of the equation in a clinical trial. There’s who has control, who gets the reward, and who takes the risk. Patients take all the risk, they have no control, and they get no reward. Patients ought to be the ones driving the process and get the reward out of it and have the control, since they are the ones that take the risk.”


~Greg Simons~


If we are taking all the risk, shouldn’t we have a say in our Destiny?
“We need to all work together for the common good of the Melanoma Patients”
“We need to take greed out of the equation and just do what is ethically for humanity”

~Jimmy B~

Which elevator will you, The Pharmaceuticals Companies will Take?



Take Care,

Jimmy B