Base on my knowledge there are at least five things you need to accomplish before an immune response can be generated:
1. You need the correct antigen to be presented by the (APC) Antigen presenting cell at the TCR T Cell receptor
2. You need to Activate the CD-4 + T-cell
3. You need to co-stimulate the CD28 receptor
4. You need to suppress the Treg cells
5. You need to a growth factor (IL-2) to grow your army of Cytotoxic Cells
Once activated, you need all the players to help orchestrate the immune response. This can not be done by single agent alone. The immune response has checks and balances that it must pass through. It is like opening a deposit box at the bank. You need the master key to open the first gate. Then you need two different keys to gain access to the deposit box. Plus there is a sequence of events that must be followed to gain access. If you only have one key, you will fail to open the box.
Each Drug company has a key to solving the problem. In order to get the tumor specific response the drug companies must work together.
Take Care,
Jimmy B
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