PLUS!!!!!!!!!!!!
"I was told yesterday that the "Til Harvest" that MDA,(MD Anderson) is doing is seeing more response (positive) to patients that have had IL-2 prior to using their T-cell harvested cells."
EQUALS!!!!!!!!!!!!!!!!!!!!!!
I think this will give US ALL a fighting chance.
Signal 1 from anti-CTLA-4 blockage and antigen and T cell receptor
Signal 2 IL-2 therapy
Third signal "Danger Signal" the CTLA-4 15mg/KG Dose
Three major events must occur to induce CD8+ T cell–mediated, tumor-protective immunity against syngeneic melanoma. First, the T-cell receptor must be triggered by a (or multiple) self antigen–derived peptide MHC class I complex (7–13). Therefore, this event depends entirely on appropriate antigen presentation, which is most efficiently provided by mature dendritic cells (14). Peripherally tolerant or “ignorant” self-reactive T-cell clones, once properly activated, may serve as tumor-specific effector T cells (15, 16). Second, simultaneously with T-cell receptor triggering, a distinct second costimulatory signal must be delivered, mediated by IL-2, B7-1, or B7-2, which engage IL-2 receptors and CD28 on the surface of the T cell, respectively (17). A source of these cofactors for effective CD8+ T-cell stimulation can be provided by CD4+ T cells that release critical amounts of IL-2, or by mature dendritic cells that display an increased level of B7-1/B7-2 costimulatory molecules on their cell surfaces. Third, inflammatory cytokines, including IL-1, IL-6, IL-12, and IFN-γ provide a third signal that acts directly on T cells (18), referred to as the “danger signal” (19, 20). This signal was found to optimally activate TH1 differentiation and lead to clonal expansion of T cells (18).”
Source: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=300854
I CAN SEE THE LIGHT AT THE END OF THE TUNNEL!!!!!!!!!!!!!!!!!
jIMMY b
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