I arrived at Montifore about 5:45 pm for my pj party. I t was the night of the All Star Game. Perfect, I could watch the game and give blood at the same time. You have to learn how to multi-task. So, up to 8th floor I went and checked in with the nurse at the front desk. She said “Mr. Breitfeller, you are right on time.” She then led me to a room 847 N bed 2. “This is you home for the night. Get yourself comfortable.” So, I changed into my sexy shorts that I been wearing even before I got married. You know the ones, silky and has Kings Point printed on them. The most comfortable shorts I have ever encountered. I could tell you how I come to have them but, this a family channel.
So, I jumped into the bed and the nurse Beverly started to put lines in my left arm. One line was for the Chemo in the morning, and the other to draw blood.
At 8:00 pm I got my 400 mg dose of Patrin I think. In this part of the trial, I have a 50/50 chance of receiving the drug. It could be a glucose placebo. I think I might check it out with GC-MS to get the scoop if I can get it in at Kodak. All fair in war and games. Plus I would know if I am wasting my time an efforts. Hey! What would you do in my situation? Take advantage of what you have at your disposal.
Patrin™
The treatment of metastatic cancers present serious problems for clinicians. Many cancers are not discovered at all until they have progressed to this late stage and response rates to therapy are often very low in these cancers; for example, only around 15-20% of metastatic melanoma cases respond to the commonly used chemotherapies dacarbazine and temozolomide.
Such low response rates are the result of resistance. Cells become resistant due to the presence of AGT (O6-alkylguanine DNA-alkyltransferase). AGT detects and specifically removes alkylated base damage, effectively undoing the damage caused by alkylating chemotherapies.
Patrin™, an orally bioavailable small molecule, acts to increase the responsiveness of tumour cells to alkylating chemotherapy treatments by specifically inactivating cellular AGT, making cancer cells susceptible to the DNA damage caused by chemotherapy
Identifying new drugs and targets for melanoma therapy is critical, considering that melanoma, the most dangerous form of skin cancer, is resistant to currently available therapeutics. Much work has been focused on finding novel drugs and exploring different treatment options that could increase the overall survival of patients.
Anyway, Blood was drawn 0, 30 min., 1, 2,3,4,5,6 hours after taken Patrin . So, this part was over at 2:00 am . The next part was the dacarbazine was introduce and the blood drawn process started all over again. I did not get released until Wednesday at 3:30 pm.
My wife made the trip down to Pittsburgh and we drove back to Rochester last Night and arrived at 10:00 pm. We made a couple of stops along the way.
I am starting to see some of the side effects nausea and my blood sugar is on the rise. I will contact Heather Blair and Melissa DeMark from the Hillan Cancer Center. I’ll Let you know what they say.
That is it for now. Take Care
jimmy B.
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Greetings to One and All
This Blog is dedicated My Brother Kenny B. who passed away in the late 1970's with Cancer before the Internet.
It was he, who showed me How to live and give back. He was wise beyond his years.
Jimmy and Dee
Carepage: Jimmybreitfeller
Jimmy Breitfeller
It was he, who showed me How to live and give back. He was wise beyond his years.
Jimmy and Dee
Carepage: Jimmybreitfeller
Jimmy Breitfeller
My Profile as of 2009
- jimmy_B
- Last July (2005)I was riding my bicycle to work at the Eastman Kodak Research Labs about 3 miles from home. I was wearing a knapsack to carry my things to and from the labs. I started noticing an ache on my back. So I decide to go to the dermatologist. To make the long story short, it was cancer. I knew from my research that I would be needing adjuvant therapy. So I started communicating with Sloan Kettering, University of Pittsburgh Cancer Center, and a couple of others including the Wilmot Cancer Center at Strong. I realized that by telling my story, I might help someone else out there in a similar situation. So to all who are linked by diagnosis or by relation to someone with melanoma, I wish you well. Stay positive, read as much as you can (information helps to eliminate the fear associated with the unknown), and live for today, as no one can predict what tomorrow may bring. Jimmy B. posted 12/15/08
Public Service Announcement
A call for Melanoma Patients by Dr. Steven A Rosenberg
"We continue to see a high rate of clinical responses in our cell transfer immunotherapy treatments for patients with metastatic melanoma", Dr. Rosenberg said.
"We are actively seeking patients for these trials and any note of that on a patient-directed web site would be appreciated."
If you would like to apply for his trials, here is the website and information.
Dr. Rosenberg's information
Dr. Rosenberg's Clinical Trials
The Melanoma Research Alliance has partnered with Bruce Springsteen, the E Street Band, and the Federici family to alleviate suffering and death from melanoma. Please view Bruce Springsteen’s public service announcement inspired by Danny Federici. Danny was the E Street Band’s organist and keyboard player. He died on April 17, 2008 at Memorial Sloan-Kettering Cancer Center in New York City after a three year battle with melanoma.
http://www.melanomaresearchalliance.org/news/PSA/
Source Fastcures blog
"We continue to see a high rate of clinical responses in our cell transfer immunotherapy treatments for patients with metastatic melanoma", Dr. Rosenberg said.
"We are actively seeking patients for these trials and any note of that on a patient-directed web site would be appreciated."
If you would like to apply for his trials, here is the website and information.
Dr. Rosenberg's information
Dr. Rosenberg's Clinical Trials
The Melanoma Research Alliance has partnered with Bruce Springsteen, the E Street Band, and the Federici family to alleviate suffering and death from melanoma. Please view Bruce Springsteen’s public service announcement inspired by Danny Federici. Danny was the E Street Band’s organist and keyboard player. He died on April 17, 2008 at Memorial Sloan-Kettering Cancer Center in New York City after a three year battle with melanoma.
http://www.melanomaresearchalliance.org/news/PSA/
Source Fastcures blog
Join the Relay for Life!!!
Dear Family and Friends,
I’ve decided to take a stand and fight back against cancer by participating in the American Cancer Society Relay For Life® event right here in my community! Please support me in this important cause by making a secure, tax-deductible donation online using the link below.
To donate on line now, click here to visit my personal page.
Jimmy B AKA Melanoma_Missionary
Relay For Life® is a life-changing event that brings together more than 3.5 million people worldwide to:
CELEBRATE the lives of those who have battled cancer. The strength of survivors inspires others to continue to fight.
REMEMBER loved ones lost to the disease. At Relay, people who have walked alongside people battling cancer can grieve and find healing.
FIGHT BACK. We Relay because we have been touched by cancer and desperately want to put an end to the disease.
Whatever you can give will help - it all adds up! I greatly appreciate your support and will keep you posted on my progress.
Keep the Fire Burning!!!
Sincerely,
Jimmy Breitfeller
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