Adoptive Immunotherapy of Cancer using CD4+ T cells.Melanoma..Jim Breitfeller

Adoptive immunotherapy of cancer using CD4+ T cells
Pawel Muranski and Nicholas P Restifo

I have been in contact with Dr. Restifo and he was so generous to share his Research papers with us.

As I started to read this one, I thought it would be better to put it in the shared file on Melanoma Missionary. I think it may interest many patients.

Adoptive immunotherapy of cancer using CD4+ T cells




Hi Jim,


Thanks for the update of your analysis of the work. Have you had any luck posting this on the Wiki site? Here’s a stack of some of our recent papers. Almost all of our papers before 2008 are available on www.pubmed.org.

Best regards,

Nick


Nicholas P Restifo, MD

Principal Investigator

National Cancer Institute

Abstract:
CD4+ T cells are central to the function of the immune system
but their role in tumor immunity remains underappreciated. It is
becoming clear that there is an enormous diversity of CD4+
T cell polarization patterns including Th1, Th2, Th17, and
regulatory T cells (Tregs). These functionally divergent T cell
subsets can have opposing effects — they can trigger tumor
rejection or inhibit treatment after adoptive cell transfer. Some
polarized CD4+ cells have plasticity, and their phenotypes and
functions can evolve in vivo. Recent advances in understanding
of polarization and differentiation of lymphocytes, as well as
some intriguing developments in the clinic, indicate that the use
of CD4+ T cell subsets in the immunotherapy of cancer has
unrealized potential.

Take care

Jimmy B
Melanoma_Missionary


"Today might be the worst day of your life...but tomorrow could be the best. You just have to get there."
~Unknown~




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Take Care,

Jimmy B