This paper is very technical but gives great insight into Melanoma and the pathways that are associated with it. It is quite long and should be read in small bites. Please don't be intimidated by it.
Giuseppe Palmieri1, MariaElena Capone2, MariaLibera Ascierto2, Giusy Gentilcore2, David F. Stroncek3, Milena Casula1, MariaCristina Sini1, Marco Palla2, Nicola Mozzillo2, and Paolo A. Ascierto*2
ABSTRACT
The characterization of the molecular mechanisms involved in development and progression of melanoma could be helpful to identify the molecular profiles underying aggressiveness, clinical behavior, and response to therapy as well as to better classify the subsets of melanoma patients with different prognosis and/or clinical outcome. Actually, some aspects
regarding the main molecular changes responsible for the onset as well asthe progression of melanoma toward a more aggressive phenotype have been described. Genes and molecules which control either cell proliferation, apoptosis, or cell senescence have been implicated. Here we provided an overview of the main molecular changes underlying thepathogenesis of melanoma. All evidence clearly indicates the existence of a complex molecular machinery that provides checks and balances in normal melanocytes. Progression from normal melanocytes to malignant metastatic cells in melanoma patients is the result of a combination of downor up-regulation of various effectors acting on different molecular pathways.
Source:
http://www.translational-medicine.com/content/pdf/1479-5876-7-86.pdf
Main Roads to Melanoma
Take Care,
Jimmy B
No comments:
Post a Comment