Update on Topical Imiquimod ..It seems to be working!!.Melanoma..Jim Breitfeller

Update on Topical Imiquimod ..It seems to be working!!!!

Imiquimod: Unexpected Killer



How might imiquimod activate the apoptotic program in melanoma cells? Several pathways leading to the induction of apoptosis have been described over the last years. Schön et al started to examine the role of these different cell death pathways and first showed that imiquimod-induced apoptosis requires the activation of the "work horses" of apoptosis necessary for the unique phenotype of apoptotic cells, namely, the caspase family of proteases (Nicholson, 1999). A widely studied pathway for the induction of apoptosis is the "extrinsic" cell death pathway, when apoptosis is triggered from the outside of the cell by death receptors like TNF-R1, TRAMP, CD95, TRAIL-R1 and -R2, DR6, and EDA-R (Locksley et al, 2001).

Source:http://www.nature.com/jid/journal/v122/n5/full/5602304a.html

Imiquimod: Unexpected Killer


Take Care,

Jimmy B