"Depletion of TREG cells using CD25-specific (mAbs) monoclonal antibodies has been shown to promote rejection of several transplantable murine tumour cell lines, including melanoma, fibrosarcoma, leukaemia and colorectal carcinoma. These studies imply that TREG cells normally inhibit the generation of effective T cell-dependent anti-tumour immune responses. These finding have been confirmed in the clinical setting, where the prevalence of TREG cells was found to be increased in the peripheral blood and tumour microenvironment of cancer patients."
We just need to break the imbalance and generate an immune response.
"IL-2 has been shown to be essential for the generation of TREG cells in the thymus and their survival, expansion and suppressive function in
the periphery [69]. IL-2-, and IL-2R-deficient mice develop T-cell lympho-proliferation and lethal autoimmunity, very probably due to lack of
activation-induced cell death (AICD) and lack of T REG cells. Furthermore, in vivo IL-2 neutralisation by use of an IL-2 blocking antibody also induces autoimmune diseases in mice. The detailed molecular mechanisms of the effects of IL-2 in the homeostasis and suppressive function of TREG cells have still to be clarified."
Source:http://www.smw.ch/docs/pdf200x/2007/45/smw-11916.PDF
"CD4+CD25+Foxp3+ regulatory T cells: frombasic research to potential therapeutic use"
Christian Motteta, Dela Golshayanb
a Division of Gastroenterology & Hepatology, BH-10N-545, Centre Hospitalier Universitaire
Vaudois (CHUV), Lausanne, Switzerland
b Division of Nephrology & Transplantation Centre, Centre Hospitalier Universitaire Vaudois
(CHUV), Lausanne, Switzerland
Take care
Jimmy B
No comments:
Post a Comment