www.aacrjournals.org Clin Cancer Res 2007;5271 13(18) September 15, 2007
Authors: Xingxing Zang and James P. Allison
Abstract: "The activation and development of an adaptive immune response is initiated by the engagement of aT-cell antigen receptor by an antigenic peptide-MHCcom plex.The outcome of this engagement is determined by both positive and negative signals, costimulation and coinhibition, generated mainly by the interaction between the B7 family and their receptor CD28 family. The importance of costimulation and coinhibition of T cells in controlling immune responses is exploited by tumors as immune evasion pathways. Absence of the expression of costimulatory B7 molecules renders tumors invisible to the immune system, whereas enhanced expression of inhibitory B7 molecules protects them from effectiveTcell destruction. Therefore, the manipulation of these pathways is crucial for developing effective tumor immunotherapy.Translation of our basic knowledge of costimulation and coinhibitioninto early clinical trials has shown considerable promise."
Source:http://clincancerres.aacrjournals.org/cgi/reprint/13/18/5271.pdf
The B7 Family and Cancer Therapy: Costimulation and Coinhibition
If you do anything, Please read this paper!!!
Jimmy B
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