Blockade of CTLA-4 (CD152) enhances the murine antibody response Melanoma..Jim Breitfeller

"Kinetic analysis revealed that the stimulation generated by anti-CTLA-4 administration was not yet obvious after 3 days, except for serotype 3, for which a small stimulation was observed. Seven days after anti-CTLA-4 treatment, a clear and significant stimulation was observed that was comparable with the stimulation found after 14 days".

and

"The effect of anti-CTLA-4 treatment on the anti-caps-PS immune response was dose-dependent. A 2.3-fold increase of the specific anti-caps-PS immune response to serotype 3 was observed after administration of 200 µg 4F10, whereas an eightfold increase was observed after administration of 400 µg 4F10 (data not shown)."


Source:http://www.jleukbio.org/cgi/content/full/78/5/1060?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=anti-ctla-4&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT



I believe the puzzle is coming togther very nicely. Now all we have to do is get the Oncologists on board.

Jimmy B