Was it a Placebo or was it Memorex???????? Why did my Blood Sugar Spike to 300 mg/dl , when the norm is 90-110 mg/dl???
I started to jump to the conclusion, that I was given a placebo. The data that I had to work with showed a jump in my blood sugar level.
The first reading is in the am and the second is pm.
Date Data mg/dl
7/8 130/ 73
7/9 151/77
7/10 126/129
7/11 no readings (Having a great time with Margaret and Caroline) I was a bad boy!!! Patrin started
7/12 256/247 Dacarbazine started
7/13 297/163/158 10 units of insulin injected
7/14 148
I wanted to know what caused the spike in Blood Sugar Level?
I began to use my research skills on the internet and got both MSDS sheets (Material safety Data sheets) for each of the compounds.
I start with Patrin aka Carbaryl 1-Naphthalenol methylcabamate. M.W. 201.22
Molecule Forumla C12H11NO2
Water Solubility ----- Insoluble 0.00826 g/100 mL
This compound doesn’t look like it would breakdown into an alcohol easily. So, I ruled out that patrin was the cause. Could it be a sugar placebo? On 7/13 the 158 reading was taken 1 hour after taking the Patrin. This indicated that the patrin was the real thing and not a placebo. I will double check this morning after I take the patrin again. I will repeat the experiment and make sure I get similar results.
Next, I looked up Dacarbazine For Injection. One problem, I did not know the manufacturer. I used Teva Sicor as the manufacturer. But, I assume the formulation would be similar.
DTIC…… 5-(3,3-Dimethyl-1triazeno) imidazold-4-carboxamide
Molecule Formula C6H10N6O
Water Solubility----- Slightly
The DTIC did not look like it would convert to a sugar readily. So there is something more going on. If it is only slightly soluble in water, they would alter the composition to make it more soluble. So I went to the Composition and Active ingredients section of the Material safety data sheet. And there it was. It stood out like a soar thumb. It was a mixture of three compounds. Dacarbazine, Citric Acid, Anhydrous, and Mannitol.
Mannitol was the culprit.
1,2,3,4,5,6-Hexanehexol AKA Manna Sugar
Molecular Formula HOCH2(CHOH)4CH2OH
Water soluble
It could be any where from 10 to 20 Percent by weight.
The mystery is solved!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
It was the Mannitol causing the spike in my Blood Sugar Level. I will verify it on my next cycle of Chemotharapy. (August 2nd)
That it from here.
I have some letters to write to my lovely Ladies
Take Care
P.S Anne M, I solved the mystery without spending a dime on GC-MS. Kodak would be proud of me. I kept down the charge rate. Only Kidding
Thanks for stirring up my research skills again. It would be very nice to get back to Work!!!!!!!!!
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