I arrived at Montifore about 5:45 pm for my pj party. I t was the night of the All Star Game. Perfect, I could watch the game and give blood at the same time. You have to learn how to multi-task. So, up to 8th floor I went and checked in with the nurse at the front desk. She said “Mr. Breitfeller, you are right on time.” She then led me to a room 847 N bed 2. “This is you home for the night. Get yourself comfortable.” So, I changed into my sexy shorts that I been wearing even before I got married. You know the ones, silky and has Kings Point printed on them. The most comfortable shorts I have ever encountered. I could tell you how I come to have them but, this a family channel.
So, I jumped into the bed and the nurse Beverly started to put lines in my left arm. One line was for the Chemo in the morning, and the other to draw blood.
At 8:00 pm I got my 400 mg dose of Patrin I think. In this part of the trial, I have a 50/50 chance of receiving the drug. It could be a glucose placebo. I think I might check it out with GC-MS to get the scoop if I can get it in at Kodak. All fair in war and games. Plus I would know if I am wasting my time an efforts. Hey! What would you do in my situation? Take advantage of what you have at your disposal.
Patrin™
The treatment of metastatic cancers present serious problems for clinicians. Many cancers are not discovered at all until they have progressed to this late stage and response rates to therapy are often very low in these cancers; for example, only around 15-20% of metastatic melanoma cases respond to the commonly used chemotherapies dacarbazine and temozolomide.
Such low response rates are the result of resistance. Cells become resistant due to the presence of AGT (O6-alkylguanine DNA-alkyltransferase). AGT detects and specifically removes alkylated base damage, effectively undoing the damage caused by alkylating chemotherapies.
Patrin™, an orally bioavailable small molecule, acts to increase the responsiveness of tumour cells to alkylating chemotherapy treatments by specifically inactivating cellular AGT, making cancer cells susceptible to the DNA damage caused by chemotherapy
Identifying new drugs and targets for melanoma therapy is critical, considering that melanoma, the most dangerous form of skin cancer, is resistant to currently available therapeutics. Much work has been focused on finding novel drugs and exploring different treatment options that could increase the overall survival of patients.
Anyway, Blood was drawn 0, 30 min., 1, 2,3,4,5,6 hours after taken Patrin . So, this part was over at 2:00 am . The next part was the dacarbazine was introduce and the blood drawn process started all over again. I did not get released until Wednesday at 3:30 pm.
My wife made the trip down to Pittsburgh and we drove back to Rochester last Night and arrived at 10:00 pm. We made a couple of stops along the way.
I am starting to see some of the side effects nausea and my blood sugar is on the rise. I will contact Heather Blair and Melissa DeMark from the Hillan Cancer Center. I’ll Let you know what they say.
That is it for now. Take Care
jimmy B.
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