Plasticity of Macrophage Function during Tumor Progression: Regulation by Distinct Molecular Mechanisms

Plasticity of Macrophage Function during Tumor Progression: Regulation by Distinct Molecular Mechanisms





“It is not the strongest of the species that survives, nor the most intelligent, but the one most responsive to change.”



~Charles Darwin~

Take Care,

Jimmy B

IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells

IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells

“It is not the strongest of the species that survives, nor the most intelligent, but the one most responsive to change.”~Charles Darwin~Take Care,Jimmy B

Immunotherapy.. The Magic Bullet.. The Breakthrough Therapy.. the Paradigm Shift.. The Future

I wrote about this as the "Magic bullet" back in 2009.Great insight in where immunotherapy is heading in the future.



When you combine anti-CD47 therapy with checkpoint therapy (anti-PD1 and or anti-CTLA4/Yervoy), you involve the innate and the adoptive immune system to eradicate cancer (Melanoma)
 I would like to see combinatorial therapy with checkpoint inhibitors like yervoy/anti-CTLA-4 & anti-PD-1along with anti-CD47 to eliminate the "don't eat me" signal, so the macrophages can get involved with the tumor elimination.

http://www.youtube.com/watch?v=XGeqAEr1RnE&feature=share


“It is not the strongest of the species that survives, nor the most intelligent, but the one most responsive to change.” ~Charles Darwin~

Take Care,

Jimmy B